GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs515910 | 1 | rs591784 | chr10:105936290 | C10orf79 | chr10:105889647-105992120:- | 0.25 | 8 | 9.29E-15 | Attention deficit hyperactivity disorder |
| THCA | cis | rs4888671 | 1 | rs59181394 | chr16:77785955 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.91 | 1.25E-6 | Obesity-related traits |
| THCA | cis | rs614226 | 1 | rs591992 | chr12:121019323 | COQ5 | chr12:120941083-120966964:- | 0.14 | 3.51 | 0.000487 | Type 1 diabetes nephropathy |
| THCA | cis | rs614226 | 1 | rs591992 | chr12:121019323 | POP5 | chr12:121016849-121019201:- | -0.16 | -4.88 | 1.45E-6 | Type 1 diabetes nephropathy |
| THCA | cis | rs12435908 | 1 | rs59204447 | chr14:66106727 | LOC645431 | chr14:65877313-65879335:- | -0.61 | -7.9 | 1.91E-14 | Ischemic stroke |
| THCA | cis | rs1930961 | 1 | rs59226697 | chr22:25870037 | CRYBB2 | chr22:25615612-25627836:+ | 0.76 | 8.18 | 2.58E-15 | Bipolar disorder with mood-incongruent psychosis |
| THCA | cis | rs726288 | 1 | rs59233487 | chr10:81729450 | LOC219347 | chr10:81805991-81838949:- | 0.51 | 5.21 | 2.88E-7 | Rheumatoid arthritis |
| THCA | cis | rs344081 | 1 | rs59244547 | chr3:156582997 | LEKR1 | chr3:156544076-156763918:+ | -0.54 | -10.49 | 2.67E-23 | Bone mineral density |
| THCA | cis | rs6479891 | 1 | rs59246603 | chr10:65233942 | LOC84989 | chr10:65224989-65226320:+ | 0.25 | 4.08 | 5.18E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs59246603 | chr10:65233942 | NRBF2 | chr10:64893007-64914785:+ | 0.26 | 4.32 | 1.92E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs7606754 | 1 | rs59257065 | chr2:228179328 | MFF | chr2:228189978-228222547:+ | 0.22 | 4.87 | 1.53E-6 | Corneal structure |
| THCA | cis | rs9902453 | 1 | rs59274738 | chr17:28437635 | ANKRD13B | chr17:27916801-27941778:+ | 0.35 | 8.82 | 2.19E-17 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs59274738 | chr17:28437635 | CORO6 | chr17:27941774-27948441:- | 0.51 | 12.02 | 2.86E-29 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs59274738 | chr17:28437635 | EFCAB5 | chr17:28256874-28435469:+ | 0.59 | 11.34 | 1.53E-26 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs59274738 | chr17:28437635 | GIT1 | chr17:27900487-27916610:- | 0.28 | 6.61 | 1.04E-10 | Coffee consumption (cups per day) |